I. Gupta

ANOMALY: A Snakemake pipeline for identifying NuMTs from Long-Read Sequencing Data

ANOMALY identifies NuMTs from long-read sequencing data with high accuracy, demonstrating the advantages of long-read over short-read data for resolving complex NuMTs.

Triphasic Thrombosis Model: A Computational Study of Type B Aortic Dissection

The paper develops a computational model of thrombosis using porous media theory to simulate thrombus growth in type B aortic dissection and compares results with MRI data.

PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS

This study shows that host evolution against coinfections is influenced by the growth and virulence dynamics of individual pathogens, with fast-acting pathogens hindering adaptive success.

Benchmarking robust spatial transcriptomics approaches to capture the molecular landscape and pathological architecture of archived cancer tissues

This study benchmarks spatial transcriptomics methods on archived FFPE cancer tissues, revealing molecular landscapes and pathological features, including non-coding RNA expression.

Sustained pigmentation causes DNA damage and invokes translesion polymerase Pol κ for repair in melanocytes

This study shows sustained melanogenesis causes DNA damage in melanocytes, invokes Pol κ for repair, and links Pol κ activity to genome instability and mutational load in melanoma.

Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.

Single Cell RNA-sequencing reveals cellular heterogeneity, stage transition and antigenic variation during stress adaptation in synchronized Plasmodium falciparum

This study uses scRNA-seq to analyze cellular heterogeneity and stress adaptation in Plasmodium falciparum under temperature stress, identifying gametogenesis primed cells and stress response mechanisms.