J. Crawford

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

The effect of clinically relevant beta-lactam, aminoglycoside, and quinolone antibiotics on bacterial extracellular vesicle release from E. coli

This study examines how clinically relevant antibiotics affect extracellular vesicle release from E. coli, finding that beta-lactams increase release while quinolones and aminoglycosides decrease it.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Identification of efflux substrates using a riboswitch-based reporter in Pseudomonas aeruginosa

This paper identifies efflux substrates in Pseudomonas aeruginosa using a riboswitch-based reporter system to distinguish compounds that enter the cell and avoid efflux from those that are exported.

Benchmarking robust spatial transcriptomics approaches to capture the molecular landscape and pathological architecture of archived cancer tissues

This study benchmarks spatial transcriptomics methods on archived FFPE cancer tissues, revealing molecular landscapes and pathological features, including non-coding RNA expression.

Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus Infection

This study shows that cGAS-STING restricts RNA viruses by sensing endogenous DNA ligands, promoting a preparatory immune state even in the absence of viral DNA.