Author

Y. J. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

G. Xie· 3 shared J. Irianto· 3 shared L. Zhang· 2 shared O. H. Usman· 2 shared S. Kumar· 2 shared A. Aimard· 1 shared A. Fernandez· 1 shared A. Holguin-Horcajo· 1 shared

Activity by Year

2021-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

G. Xie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Y. J. Wang, A. Yemelyanov, C. D. Go, S. Kim, J. M. Quinn, A. S. Flozak, P. M. Le, S. Liang, A.-C. Gingras, M. Ikura, N. Ishiyama, C. J. Gottardi

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Journal of Cell Biology · Jan 9, 2025Peer-reviewedCell Biology

A single-cell atlas of the murine pancreatic ductal tree identifies novel cell populations with potential implications in pancreas regeneration and exocrine pathogenesis.

A. Fernandez, J. Casamitjana, A. Holguin-Horcajo, K. Coolens, L. Mularoni, L. Pasquali, J. M. Bailey-Lundberg, I. Rooman, Y. J. Wang, M. Rovira

This study identifies 15 novel ductal cell populations in the mouse pancreas using scRNA-seq and investigates their roles in regeneration and exocrine pathogenesis.

bioRxiv · Feb 26, 2024Cell Biology

Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

O. H. Usman, S. Kumar, R. R. Walker, G. Xie, H. Sumajit, A. R. Jalil, S. Ramakrishnan, L. J. Dooling, Y. J. Wang, J. Irianto

This study shows that ECM proteins differentially affect morphology, proliferation, and drug sensitivity in primary but not metastatic pancreatic cancer cells, with transcriptomic changes in primary cells.

bioRxiv · Nov 11, 2022Cancer Biology

Phenotypic, genomic, and transcriptomic heterogeneity in a pancreatic cancer cell line

G. Xie, L. Zhang, O. H. Usman, S. Kumar, C. Modak, D. Patel, M. Kavanaugh, X. Mallory, Y. J. Wang, J. Irianto

The paper characterizes phenotypic, genomic, and transcriptomic heterogeneity in MIA PaCa-2 pancreatic cancer cell clones, showing distinct traits and suggesting its use as a model for studying cancer heterogeneity.

bioRxiv · Nov 11, 2022Cancer Biology

Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

Y. J. Wang, C. Valotteau, A. Aimard, L. Villanueva, D. Kostrz, M. Follenfant, T. Strick, P. Chames, F. Rico, C. Gosse, L. Limozin

The paper combines DNA scaffolds and acoustic force spectroscopy to measure single-molecule protein bond rupture under force, showing agreement with standard techniques.

bioRxiv · Aug 14, 2022Biophysics

Genomic heterogeneity in pancreatic cancer organoids and its stability with culture

O. Usman, L. Zhang, G. Xie, H. M. Kocher, C.-i. Hwang, Y. J. Wang, X. F. Mallory, J. Irianto

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

bioRxiv · Jul 3, 2022Cancer Biology

Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal

K. Jin, E. E. Bardes, A. Mitelpunkt, Y. J. Wang, S. Bhatnagar, S. Sengupta, D. P. Krummel, M. E. Rothenberg, B. J. Aronow

The paper creates a web portal to compare single-cell transcriptome data from COVID-19 and control samples, identifying gene and cell network hypotheses related to differential host responses.

bioRxiv · Jun 7, 2021Immunology