A genome-wide catalog of sites where peripheral DNA methylation reflects the brain
Shota Nishitani, Shizhong Han, Takaya Ishii, Akiyoshi Shimura, Nathan James Phuong, Asahi Kato, Meagan Chambers, Tao Wang, Makoto Isozaki, Yoshifumi Higashino, Takahiro Yamauchi, Satoshi Kawajiri, Hidetaka Arishma, Toshiaki Kodera, Hirochika Imoto, , Gen Shinozaki
The paper identifies brain-peripheral DNA methylation sites (BrESS) that consistently predict brain methylation across tissues, showing they are not linked to disease heritability.
bioRxiv · Oct 24, 2026 · PreprintNeuroscience