Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI
Edward D. B. Lopatto, Jesús M. Santiago-Borges, Denise A. Sanick, Sameer Kumar Malladi, Philippe N. Azimzadeh, Morgan R. Timm, Isabella F. Fox, Aaron J. Schmitz, Jackson S. Turner, Shaza M. Sayed Ahmed, Lillian Ortinau, Nathaniel C. Gualberto, Jerome S. Pinkner, Karen Dodson, Ali H. Ellebedy, , Scott J. Hultgren
This study identifies two monoclonal antibodies against FimH adhesin that protect mice from E. coli UTI by sterically blocking FimH function, offering an antibiotic-sparing treatment strategy.
Science Advances · Jun 20, 2025Peer-reviewedMicrobiology