Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.
Thi Mai Loan Nguyen, Jean‐Philippe Guilloux, Céline Defaix, Indira Mendez‐David, Isabelle Etting, Jean‐Claude Alvarez, Josephine Cecelia McGowan, Jaclyn N. Highland, Panos Zanos, Jacqueline Lovett, Ruin Moaddel, Emmanuelle Corruble, Denis Joseph Paul David, Todd D. Gould, Christine Ann Denny, Alain Michel Gardier
The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.
Neuropharmacology · Jul 14, 2024Peer-reviewedNeuroscience