John A. G. Briggs

This study determines the molecular mechanism of M1-mediated influenza A virus assembly by analyzing M1's conformational states and interactions in virions.

This study determines the structure of the COPI vesicle coat with GOLPH3 and shows how it preferentially binds Golgi residents at late cisternae through coincidence detection of COPI and lipid.

This study uses cryo-ET to visualize copia retrotransposon structure in Drosophila cells, revealing nuclear clustering and size selection during gametogenesis.

This study identifies SP2 as a trigger for HIV-1 MA lattice maturation, showing it binds MA to induce structural changes and enhance viral infectivity.

This paper develops a physical model explaining how M1 protein polymerization into helices facilitates efficient influenza A virus assembly and membrane deformation.

The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.

This study uses cryo-correlative light and electron microscopy to investigate the ultrastructure and dynamics of dopaminergic presynaptic release sites and identifies protein complexes and modulatory effects of pharmacological treatments.

This study shows PNMA2 forms virus-like capsids that trigger an autoimmune response, leading to paraneoplastic neurological syndrome.

The paper elucidates the structural basis of retromer core trimer assembly with SNX3, showing how it forms tubular carriers and incorporates cargo through conserved interfaces linked to Parkinson's disease mutations.

This study uses cryo-electron tomography to reveal the 3D molecular architecture of glutamatergic synapses in the adult mammalian forebrain, showing a synaptoplasm rather than a distinct PSD.

The paper determines the structure and interactions of AP2 and clathrin during clathrin-coated vesicle formation using cryo-EM and tomography.

This study identifies how complexin suppresses spontaneous exocytosis by binding the membrane-proximal regions of VAMP2 and SNAP25.

The paper reports the structure of virus-like capsids formed by Drosophila Arc proteins and shows their similarity to retroviral and retrotransposon capsids.