Author

J. A. Boyce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:scRNA-seq· 5 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3

Frequent Co-Authors

T. M. Laidlaw· 5 shared N. A. Barrett· 4 shared N. Bhattacharyya· 4 shared K. M. Buchheit· 3 shared A. Boyd· 2 shared A. K. Shalek· 2 shared A. L. Haber· 2 shared A. Maxfield· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersImmunology

T. M. Laidlaw

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Author profile →

6 papers

Recent·Most cited

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

N. A. Barrett, G. X. Huang, N. R. Hallen, M. Lee, K. Zheng, X. Wang, M. V. Mandanas, S. Djeddi, D. Fernandez, J. Hacker, T. Ryan, R. W. Bergmark, N. Bhattacharyya, S. Lee, A. Z. Maxfield, , M. Gutierrez-Arcelus

The paper identifies increased mTORC1 activity in CRSwNP epithelial cells and links it to cytokine production and inflammation in both CRSwNP and asthma.

bioRxiv · Oct 13, 2023 · PreprintImmunology

Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling

X. Wang, N. Hallen, M. Lee, S. Samuchiwal, Q. Ye, K. Buchheit, A. Maxfield, R. Roditi, R. Bergmark, N. Bhattacharyya, T. Ryan, D. Gakpo, S. Raychaudhuri, D. Dwyer, T. M. Laidlaw, , N. Barrett

This study identifies BCAM as a marker of airway basal stem cells and shows that T2 cytokines drive their expansion via IRS signaling in CRSwNP.

bioRxiv · Oct 13, 2022Immunology

TRPM5+ microvillous tuft cells regulate neuroepithelial intrinsic olfactory stem cell proliferation.

S. Ualiyeva, E. R. Lemire, A. Boyd, C. Wong, E. C. Aviles, A. Perniss, D. Minichetti, A. Maxfield, R. Roditi, N. Barett, N. Barett, K. M. Bucheit, T. M. Laidlaw, J. A. Boyce, L. G. Bankova, A. L. Haber

The paper identifies TRPM5+ olfactory microvillous cells as tuft cells and shows their role in regulating olfactory stem cell proliferation in response to allergens.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

S. Ualiyeva, E. R. Lemire, E. C. Aviles, A. Boyd, C. Wong, J. Lai, T. Liu, I. Matsumoto, N. A. Barrett, J. A. Boyce, A. L. Haber, L. Bankova

The paper shows that tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically drive lung type 2 inflammation in response to aeroallergens.

bioRxiv · Sep 26, 2021Immunology

IL-5Rα marks nasal polyp IgG4 and IgE-secreting cells in aspirin-exacerbated respiratory disease

K. M. Buchheit, D. F. Dwyer, J. Ordovas-Montanes, H. R. Katz, E. Lewis, N. Bhattacharyya, A. K. Shalek, N. A. Barrett, J. A. Boyce, T. M. Laidlaw

This study identifies IL-5Rα-expressing IgG4 and IgE-secreting cells in nasal polyps of AERD patients, linking them to disease severity and local antibody production.

bioRxiv · Jan 23, 2019 · PreprintImmunology

Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity

J. Ordovas-Montanes, D. F. Dwyer, S. K. Nyquist, K. M. Buchheit, C. Deb, M. H. Wadsworth, T. K. Hughes, S. W. Kazer, E. Yoshimoto, N. Bhattacharyya, H. R. Katz, T. M. Laidlaw, J. A. Boyce, N. A. Barrett, A. K. Shalek

This study profiles single-cell RNA-seq data from human respiratory tissues to show reduced epithelial diversity and altered basal progenitor states in type 2 immunity-driven diseases.

bioRxiv · Nov 14, 2017Immunology