Y. Bykov

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

Mitochondrial ribosomal proteins developed unconventional mitochondrial targeting signals due to structural constraints

The paper identifies internal mitochondrial targeting signals in yeast mitochondrial ribosomal proteins, showing that 30% of them use non-conventional signals not reliably predicted by existing methods.

Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

The paper introduces a method using fluorescent barcoding and electron microscopy to enable high-throughput screening of ultrastructural phenotypes in yeast.