C. A. Loynes

Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes

The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.

Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System

The paper identifies homology between zebrafish and human distal urinary tract anatomy, including a functional urinary bladder in adult zebrafish.

A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo.

This paper develops a zebrafish model expressing p21-GFP to study senescence and test senolytics, showing that quercetin and dasatinib reduce senescent cells in a 5-day assay.

Deletion of cftr leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammation

This study shows that CFTR deletion in zebrafish causes excessive neutrophilic inflammation and impaired tissue repair, which can be mitigated by Tanshinone IIA.

Endogenous pioneer neutrophils release NETs during the swarming response in zebrafish

This study shows that endogenous neutrophils in zebrafish release NETs during the swarming response, revealing a potential role for NETosis in driving this process.

The CXCL12/CXCR4 signalling axis retains neutrophils at inflammatory sites in zebrafish

This study shows that CXCL12/CXCR4 signaling retains neutrophils at inflammatory sites in zebrafish, and its inhibition accelerates inflammation resolution by promoting reverse migration.

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

This study shows that PGE2 promotes neutrophil reverse migration and anti-inflammatory signaling, aiding inflammation resolution in a zebrafish model.