Author

J. A. Pachter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. A. Seyhan· 1 shared A. M. Barrie· 1 shared A. M. Mark· 1 shared A. Molinolo· 1 shared A. Navaraj· 1 shared B. Gyorffy· 1 shared C. J. Diaz Osterman· 1 shared C. Jean· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. A. Seyhan

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Author profile →

3 papers

Recent·Most cited

Hidden Interactions: Frequency-Dependence Emulates Selection-Driven Dynamics in Evolving Populations

R. J. Barker-Clarke, J. A. Pachter, J. M. Gray, S. Leither, M. A. R. Strobl, D. S. Tadele, J. Maltas, M. Hinczewski, J. G. Scott

This paper shows that frequency-dependent interactions can mask or mimic frequency-independent selection in evolving populations, emphasizing the need to account for interactions in evolutionary inference.

bioRxiv · Mar 15, 2023 · PreprintEvolutionary Biology

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

L. Zhou, K. Huntington, S. Zhang, L. Carlsen, E.-Y. So, C. Parker, I. Sahin, H. Safran, S. Kamle, C.-M. Lee, C.-G. Lee, J. A. Elias, K. S. Campbell, M. T. Naik, W. J. Atwood, , W. El-Deiry

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

bioRxiv · Aug 2, 2020 · PreprintCell Biology

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

C. J. Diaz Osterman, D. Ozmadenci, E. G. Kleinschmidt, K. N. Taylor, A. M. Barrie, S. Jiang, L. M. Bean, F. J. Sulzmaier, C. Jean, I. Tancioni, K. Anderson, S. Uryu, E. A. Cordasco, J. Li, X. L. Chen, , D. D. Schlaepfer

This study identifies FAK activity as a driver of platinum resistance in ovarian cancer by sustaining CSC survival and DNA repair, showing that FAK inhibitors combined with platinum can overcome resistance.

bioRxiv · Mar 30, 2019Cancer Biology