Author

A. A. Seyhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

L. Zhou· 3 shared K. E. Huntington· 2 shared S. Zhang· 2 shared W. S. El-Deiry· 2 shared A. D. Louie· 1 shared A. De La Cruz· 1 shared A. E. Abbas· 1 shared A. George· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

L. Zhou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment

S. Zhang, K. E. Huntington, L. Zhou, A. A. Seyhan, B. Kun, B. A. Carneiro, J. Kreiling, J. M. Sedivy, W. S. El-Deiry

This study investigates how senescent fibroblasts influence tumor growth and immune response, showing that targeting the p21-driven SASP and combining senolytics with cancer therapies can suppress tumor growth.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

TRAIL agonists rescue mice from radiation-induced lung injury

J. Strandberg, A. D. Louie, S. Lee, M. Hahn, P. Srinivasan, A. George, A. De La Cruz, L. Zhang, L. H. Borrero, K. E. Huntington, P. De La Cruz, A. A. Seyhan, P. P. Koffer, D. E. Wazer, T. A. DiPetrillo, , W. S. El-Deiry

TRAIL agonists reduce radiation-induced lung injury and lethality in mice by inhibiting CCl22 and improving pneumonitis, alveolar-wall thickness, and oxygen desaturation.

bioRxiv · Jun 12, 2023 · PreprintPathology

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

L. Zhou, K. Huntington, S. Zhang, L. Carlsen, E.-Y. So, C. Parker, I. Sahin, H. Safran, S. Kamle, C.-M. Lee, C.-G. Lee, J. A. Elias, K. S. Campbell, M. T. Naik, W. J. Atwood, , W. El-Deiry

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

bioRxiv · Aug 2, 2020 · PreprintCell Biology