J. B. Moseley

Design principles of Cdr2 node patterns in fission yeast cells

The paper investigates how Cdr2 nodes form and position in fission yeast cells using experimental and modeling approaches, finding that tip inhibition and cortical anchoring are sufficient for node assembly without a nucleus.

The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time

This paper identifies how fission yeast switch between surface area and volume-based cell size control based on ploidy and describes the roles of Cdc25 and Cdc13 in this system.

Regulation of cell size and Wee1 by elevated levels of Cdr2

This study shows that increased Cdr2 levels in fission yeast reduce cell size by hyperphosphorylating Wee1 and sequestering it near the nucleus, inhibiting Cdk1.

Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division

This study identifies Arf6 as an anchor for Cdr2 nodes at the cell cortex, essential for surface area-based size control in fission yeast.

Pak1 kinase controls cell shape through ribonucleoprotein granules

The paper shows Pak1 kinase regulates cell shape by modulating Sts5's association with ribonucleoprotein granules through phosphorylation, affecting cell polarity and stress responses.

Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast

The paper shows that Psy1, a SNARE protein, is sequestered in Skb1-Slf1 nodes at non-growing cell sides in fission yeast, restricting exocytosis to growth sites and maintaining cell morphology.

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis

This study identifies Pak1 as a kinase that phosphorylates Mid1 to regulate cytokinesis in fission yeast by controlling CAR assembly and division plane positioning.

A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1

This study identifies how Cdr1/Nim1 kinase inhibits Wee1 to promote mitotic entry by phosphorylating specific serine residues in yeast.

The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast

This study shows that Sds23, an inhibitor of PP2A, regulates symmetric cell division in fission yeast by controlling cytokinesis positioning.

Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry

The paper shows Pom1 forms stable clusters that create a glucose-modulated gradient regulating mitotic entry in fission yeast.

Cell size-dependent regulation of Wee1 localization by Cdr2 cortical nodes

This study shows how cell growth inhibits fission yeast Wee1 through dynamic bursts of its localization to cortical nodes containing inhibitory kinases.