Author

J. B. Radke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D.-P. Hong· 3 shared M. W. White· 2 shared S. Huang· 2 shared W. J. Sullivan· 2 shared C. Mulrooney· 1 shared D. E. Goldberg· 1 shared D. Worth· 1 shared E. Comer· 1 shared

Activity by Year

2016-2018 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

D.-P. Hong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

J. B. Radke, K. L. Carey, S. Shaw, S. R. Metkar, C. Mulrooney, J. P. Gale, J. A. Bittker, R. Hilgraf, E. Comer, S. L. Schreiber, H. W. Virgin, J. R. Perez, L. D. D. Sibley

This study identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth through a high-throughput screen and characterizes their mechanisms of action.

bioRxiv · Jun 2, 2018Microbiology

Evaluation of current and emerging anti-malarial medicines for inhibition of Toxoplasma gondii growth in vitro

J. B. Radke, J. N. Burrows, D. E. Goldberg, L. D. Sibley

This study evaluates anti-malarial drugs for their ability to inhibit Toxoplasma gondii growth in vitro, finding limited effectiveness for most compounds.

bioRxiv · May 8, 2018Microbiology

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

J. B. Radke, D. Worth, D.-P. Hong, S. Huang, W. J. Sullivan, E. H. Wilson, M. White

This paper identifies AP2IV-4 as a transcriptional repressor that suppresses bradyzoite gene expression in tachyzoites, essential for establishing chronic Toxoplasma infection.

PLOS Pathogens · May 2, 2018Peer-reviewedMicrobiology

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

S. Huang, M. J. Holmes, J. B. Radke, D.-P. Hong, T.-K. Liu, M. W. White, W. J. Sullivan

This study identifies AP2IX-4 as a regulator of gene expression during bradyzoite development in Toxoplasma gondii, showing its role in cyst formation and virulence.

bioRxiv · Jan 30, 2017Microbiology

Opposing transcriptional mechanisms regulate Toxoplasma development.

D.-P. Hong, J. B. Radke, M. W. White

This study identifies opposing roles of AP2IX-9 and AP2IV-3 transcription factors in regulating bradyzoite development in Toxoplasma, with AP2IX-9 acting as a repressor and AP2IV-3 as an activator of tissue cyst formation.

bioRxiv · Dec 16, 2016Microbiology