W. J. Sullivan

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency

This study identifies eIF4E1 as a key regulator of Toxoplasma gondii latency by showing its role in translational control during encystation.

Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness

This study shows that acetylation of H2B.Z is critical for Toxoplasma gondii's growth, differentiation, and virulence.

AP2XII-2 coordinates transcriptional repression for Toxoplasma gondii sexual commitment

This study identifies AP2XII-2 as a transcription factor that represses specific genes involved in Toxoplasma gondii sexual development, including AP2X-10 and AAH1.

Eukaryotic initiation factor 2α kinases regulate virulence functions, stage conversion, and the stress response in Entamoeba invadens

m6A RNA methylation facilitates pre-mRNA 3-end formation and is essential for viability of Toxoplasma gondii

This study identifies m6A RNA methylation in Toxoplasma gondii, showing it is essential for mRNA 3-end processing and parasite viability.

TgIF2K-B is an eIF2α kinase in Toxoplasma gondii that responds to oxidative stress and optimizes pathogenicity

This study identifies TgIF2K-B as an eIF2α kinase in Toxoplasma gondii that mitigates oxidative stress and supports pathogenicity by enabling cyst formation and resisting macrophage activation.

Efficacy of Guanabenz Combination Therapy Against Chronic Toxoplasmosis Across Multiple Mouse Strains

This study evaluates combination therapies for chronic toxoplasmosis in mice, finding strain-dependent efficacy and antagonistic effects in some drug pairs.

Toxoplasma gondii AP2XII-2 contributes to proper progression through S-phase of the cell cycle

This study identifies AP2XII-2 as a cell cycle-regulated transcriptional repressor that ensures proper S-phase progression and prevents excessive bradyzoite differentiation in Toxoplasma gondii.

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

This study shows Toxoplasma gondii triggers the unfolded protein response in host cells to enhance migration and dissemination of infected cells through IRE1-mediated actin remodeling.

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

This study uses ribosome profiling to analyze gene expression changes in Toxoplasma gondii and infected human cells, revealing translational control mechanisms and host response differences.

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

This paper identifies AP2IV-4 as a transcriptional repressor that suppresses bradyzoite gene expression in tachyzoites, essential for establishing chronic Toxoplasma infection.

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

This study identifies AP2IX-4 as a regulator of gene expression during bradyzoite development in Toxoplasma gondii, showing its role in cyst formation and virulence.