M. J. Holmes

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency

This study identifies eIF4E1 as a key regulator of Toxoplasma gondii latency by showing its role in translational control during encystation.

Estimating the reproduction number, R0, from agent-based models of tree disease spread

The paper estimates the basic reproduction number R0 for tree diseases using agent-based models and applies these methods to the ash dieback epidemic in the UK.

Processive movement of Staphylococcus aureus essential septal peptidoglycan synthases is independent of FtsZ treadmilling and drives cell constriction

This study shows that FtsW/PBP1 and DivIB move processively around the division site in S. aureus, driving cell constriction independently of FtsZ treadmilling.

AP2XII-2 coordinates transcriptional repression for Toxoplasma gondii sexual commitment

This study identifies AP2XII-2 as a transcription factor that represses specific genes involved in Toxoplasma gondii sexual development, including AP2X-10 and AAH1.

m6A RNA methylation facilitates pre-mRNA 3-end formation and is essential for viability of Toxoplasma gondii

This study identifies m6A RNA methylation in Toxoplasma gondii, showing it is essential for mRNA 3-end processing and parasite viability.

Dynamics of bacterial cell division: Z ring condensation is essential for cytokinesis

The paper investigates the role of FtsZ binding proteins in bacterial cytokinesis, finding that Z ring condensation is essential for cell division.

The secreted acid phosphatase domain-containing GRA44 from Toxoplasma gondii is required for C-myc induction in infected cells

This paper identifies GRA44, a secreted phosphatase from Toxoplasma gondii, as essential for host cell cMyc upregulation and part of a translocon complex involved in effector secretion.

Convergent eusocial evolution is based on a shared reproductive groundplan plus lineage-specific plastic genes

This study identifies shared and lineage-specific genes involved in eusociality by comparing transcriptomic profiles of pharaoh ants and honey bees.

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

This study uses ribosome profiling to analyze gene expression changes in Toxoplasma gondii and infected human cells, revealing translational control mechanisms and host response differences.

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

This study identifies AP2IX-4 as a regulator of gene expression during bradyzoite development in Toxoplasma gondii, showing its role in cyst formation and virulence.