Author

J. B. Wallingford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

C. Lee· 5 shared O. Papoulas· 5 shared E. M. Marcotte· 3 shared C. Devitt· 2 shared C. L. McCafferty· 2 shared D. W. Taylor· 2 shared E. Marcotte· 2 shared J. Hibbard· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersCell Biology

C. Lee

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexes

C. L. McCafferty, O. Papoulas, C. Lee, K. H. L. Bui, D. W. Taylor, E. M. Marcotte, J. B. Wallingford

The paper defines an amino acid-resolution interactome of motile cilia using XL/MS in Tetrahymena thermophila, revealing structural and functional insights into ciliary machines and ciliopathy proteins.

bioRxiv · Jul 9, 2023 · PreprintCell Biology

Label-free proteomic comparison reveals ciliary and non- ciliary phenotypes of IFT-A mutants

j. leggere, J. Hibbard, O. Papoulas, c. Lee, C. G. Pearson, E. M. Marcotte, J. B. Wallingford

The paper applies DIFFRAC to study proteomic changes in Ift122 mutants of Tetrahymena thermophila, revealing both ciliary and non-ciliary effects of IFT-A loss.

bioRxiv · Mar 8, 2023Cell Biology

Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complex

C. L. McCafferty, O. Papoulas, M. A. Jordan, G. Hoogerbrugge, C. Nichols, G. Pigino, D. W. Taylor, J. B. Wallingford, E. M. Marcotte

The paper models the structure of the IFT-A complex using experimental and computational methods, revealing insights into ciliopathy-associated mutations.

bioRxiv · Jul 5, 2022Biochemistry

Dishevelled controls bulk cadherin dynamics and the stability of individual cadherin clusters during convergent extension

R. J. Huebner, J. B. Wallingford

This study shows planar cell polarity regulates cadherin cluster stability and size during convergent extension in Xenopus laevis.

bioRxiv · Jun 6, 2022Cell Biology

Protein turnover dynamics suggest a diffusion to capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins

J. Hibbard, N. Vazquez, R. Satija, J. B. Wallingford

The paper quantifies protein dynamics of IFT and basal body proteins in vertebrate cells, finding distinct turnover kinetics and suggesting a diffusion-to-capture mechanism for IFT recruitment to basal bodies.

bioRxiv · Nov 16, 2020Cell Biology

Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation

C. Devitt, C. Lee, R. Cox, O. Papoulas, J. Alvarado, E. Marcotte, J. B. Wallingford

This study investigates the role of Twinfilin1 in actin dynamics during vertebrate gastrulation, linking it to lamellipodial protrusion and cell polarization.

bioRxiv · Sep 3, 2020Cell Biology

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

C. Lee, R. Cox, O. Papoulas, A. Horani, K. Drew, C. Devitt, S. L. Brody, E. Marcotte, J. B. Wallingford

The paper shows that inner and outer dynein arm subunits are partitioned into non-overlapping regions within DynAPs and identifies Daap1 as a novel regulator of ODA deployment.

bioRxiv · Apr 21, 2020Cell Biology

Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

R. Huebner, A. N. Malmi-Kakkada, S. Sarikaya, S. Weng, D. Thirumalai, J. B. Wallingford

The paper shows that mechanical heterogeneity along cell-cell junctions during vertebrate axis elongation is driven by cadherin clustering and Planar Cell Polarity signaling.

bioRxiv · Feb 11, 2020Cell Biology

Evolutionary proteomics uncovers ciliary signaling components

M. A. Sigg, T. Menchen, J. Johnson, C. Lee, S. P. Choksi, G. Garcia, H. Busengdal, G. Dougherty, P. Pennekamp, C. Werner, F. Rentzsch, N. Krogan, J. B. Wallingford, H. Omran, J. F. Reiter

The paper uses proteomic analysis of cilia from diverse organisms to identify conserved ciliary proteins and their ancient signaling connections, revealing a novel protein involved in vertebrate development and human disease.

bioRxiv · Jun 22, 2017Evolutionary Biology