Author

J. E. Lemieux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

P. C. Sabeti· 3 shared A. Dauphin· 2 shared J. Luban· 2 shared L. Yurkovetskiy· 2 shared A. A. Cohen· 1 shared A. Barve· 1 shared A. Baum· 1 shared A. C. Sherman· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

P. C. Sabeti

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Analysis of the Borreliaceae Pangenome Reveals a Conserved Genomic Archictecture Across Phylogenetic Scales

J. E. Lemieux

This study analyzes the Borreliaceae pangenome to reveal conserved genomic architecture across phylogenetic scales, showing lineage-specific expansions in accessory genomes, particularly among lipoproteins.

bioRxiv · Jan 7, 2024 · PreprintMicrobiology

Protein design for evaluating vaccines against future viral variation

N. Youssef, S. Gurev, F. Ghantous, K. P. Brock, J. A. Jaimes, N. N. Thadani, A. Dauphin, A. C. Sherman, L. Yurkovetskiy, D. Soto, R. Estanboulieh, B. Kotzen, P. Notin, A. W. Kollasch, A. A. Cohen, , D. Marks

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

bioRxiv · Oct 8, 2023Immunology

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

J. E. Lemieux, W. Huang, N. Hill, T. Cerar, L. Freimark, S. Hernandez, M. Luban, V. Maraspin, P. Bogovic, K. Ogrinc, P. Lapierre, E. Lasek-Nesselquist, N. Singh, R. Iyer, D. Liveris, , K. Strle

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern

R. McNamara, J. S. Maron, H. L. Bertera, J. Boucau, V. Roy, A. K. Barczak, The Positives Study Staff, N. Franko, J. Z. Li, J. S. McLellan, M. Siedner, J. E. Lemieux, H. Chu, G. Alter

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

bioRxiv · Jun 19, 2022Immunology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

bioRxiv · Jul 4, 2020Microbiology

Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2

J. Arizti-Sanz, C. A. Freije, A. C. Stanton, C. K. Boehm, B. A. Petros, S. Siddiqui, B. M. Shaw, G. Adams, T.-S. F. Kosoko-Thoroddsen, M. E. Kemball, R. Gross, L. Wronka, K. Caviness, L. E. Hensley, N. H. Bergman, , C. Myhrvold

This paper develops SHINE, a diagnostic tool for SARS-CoV-2 detection with 90% sensitivity and 100% specificity, reducing contamination risk and enabling use outside clinical settings.

bioRxiv · May 28, 2020 · PreprintBioengineering