P. Broz

Gasdermin D is the only Gasdermin that provides non-redundant protection against acute Salmonella gut infection

This study identifies Gasdermin D as the only Gasdermin providing non-redundant protection against acute Salmonella Typhimurium gut infection by restricting bacterial loads, controlling inflammation, and preventing epithelial disruption.

The Opto-inflammasome in zebrafish: a tool to study cell and tissue responses to speck formation and cell death

This paper introduces Opto-Asc, a light-controlled inflammasome tool in zebrafish to study speck formation and cell death, finding distinct morphological features of pyroptosis in periderm cells.

Optogenetic activators of apoptosis, necroptosis and pyroptosis for probing cell death dynamics and bystander cell responses

This paper develops optoCDEs, optogenetic tools to induce apoptosis, pyroptosis, and necroptosis, and uses them to study bystander cell responses to different cell death types.

Genetic targeting of Card19 is linked to disrupted Ninj1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

This study shows that genetic targeting of Card19 disrupts Ninj1 expression, impairs macrophage cell lysis, and increases susceptibility to Yersinia infection.

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling

The paper shows that RIPK1 activates GSDME in neutrophils to promote anti-Yersinia defence through pyroptosis and IL-1β release.

Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity

This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.