Author

J. C.-Y. Tien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. Chinnaiyan· 2 shared A. Parolia· 2 shared F. Su· 2 shared T. He· 2 shared X. Cao· 2 shared Y. Qiao· 2 shared Y. Zheng· 2 shared C. Abbineni· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. M. Chinnaiyan

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2 papers

Recent·Most cited

PIKfyve controls dendritic cell function and tumor immunity

J. E. Choi, Y. Qiao, I. Kryczek, J. Yu, J. Gurkan, Y. Bao, M. Gondal, J. C.-Y. Tien, T. Maj, S. Yazdani, A. Parolia, H. Xia, J. Zhou, S. Wei, S. Grove, , A. M. Chinnaiyan

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

bioRxiv · Feb 28, 2024Cancer Biology

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

T. He, L. Xiao, Y. Qiao, O. Klingbeil, E. Young, X. S. Wu, R. Mannan, S. Mahapatra, S. Eyunni, J. C.-Y. Tien, X. Wang, Y. Zheng, N. Kim, H. Zheng, S. Hou, , A. M. Chinnaiyan

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

bioRxiv · Jan 22, 2024Cancer Biology