Author

J. D. Ernst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. Cornelius· 2 shared A. Tran· 2 shared B. S. Zha· 2 shared C. S. Lindestam Arlehamn· 2 shared P. Ogongo· 2 shared A. J. Sawyer· 1 shared B. Norris· 1 shared C. G. Feng· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

A. Cornelius

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Author profile →

7 papers

Recent·Most cited

Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection

P. Ogongo, L. Wassie, A. Tran, D. Columbus, L. Sharling, G. Ouma, S. G. Ouma, K. Bobosha, C. S. Lindestam Arlehamn, N. R. Gandhi, S. C. Auld, J. Rengarajan, C. L. Day, J. D. Altman, H. Blumberg, J. D. Ernst

The paper identifies Rare Variable Mtb Antigens (RVMA) that induce Th17 responses in human TB infection, suggesting their potential as vaccine antigens to enhance Th17 immunity.

bioRxiv · Mar 5, 2024 · PreprintImmunology

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection

W. Zheng, I.-C. Chang, J. Limberis, J. M. Budzik, B. S. Zha, Z. Howard, L. Chen, J. D. Ernst

This study identifies lysosome-poor monocyte-derived lung cells as a niche for Mtb persistence during chronic infection, suggesting a target for host-directed therapy.

bioRxiv · Jan 19, 2023Immunology

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.

P. Ogongo, A. Tran, F. Marzan, D. Gingrich, M. Krone, F. Aweeka, C. S. Lindestam Arlehamn, J. N. Martin, S. Deeks, P. W. Hunt, J. D. Ernst

The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.

bioRxiv · Jan 6, 2023 · PreprintImmunology

Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis

A. J. Sawyer, E. Patrick, J. Edwards, J. S. Wilmott, T. Fielder, Q. Yang, D. L. Barber, J. D. Ernst, W. J. Britton, U. Palendira, X. Chen, C. G. Feng

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

bioRxiv · Jul 31, 2022 · PreprintImmunology

Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early M. tuberculosis infection

B. S. Zha, L. Desvignes, T. Fergus, A. Cornelius, T.-Y. Cheng, D. B. Moody, J. D. Ernst

This study compares early infection dynamics of two M. tuberculosis strains, showing strain-specific differences in bacterial spread and immune activation.

bioRxiv · May 10, 2022Immunology

Dynamics of Mycobacterium tuberculosis Ag85B revealed by sensitive ELISA

J. D. Ernst, A. Cornelius, M. Bolz

This study develops a sensitive ELISA to quantify Ag85B secretion in M. tuberculosis and finds it varies by strain and decreases during infection.

bioRxiv · Mar 15, 2019 · PreprintMicrobiology

Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention

B. Norris, J. D. Ernst

This study investigates mononuclear cell dynamics during M. tuberculosis infection in mice, revealing rapid differentiation and bacterial acquisition by newly recruited cells, supporting host-directed therapies.

bioRxiv · Jun 14, 2018Immunology