Author

J. D. J. Sng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. A. Khromykh· 3 shared A. Slonchak· 2 shared A. Suhrbier· 2 shared F. J. Torres· 2 shared K. Yan· 2 shared R. Parry· 2 shared X. Wang· 2 shared A. A. Amarilla· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

A. A. Khromykh

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Author profile →

3 papers

Recent·Most cited

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

R. Stewart, K. Yan, S. A. Ellis, C. R. Bishop, T. Dumenil, B. Tang, W. Nguyen, T. Larcher, R. Parry, J. D. J. Sng, A. A. Khromykh, R. K. P. Sullivan, M. Lor, F. A. Meunier, D. J. Rawle, A. Suhrbier

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

bioRxiv · Dec 22, 2022 · PreprintMicrobiology

Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinant of sfRNA biogenesis and provides new insights into flavivirus evolution

A. Slonchak, R. Parry, B. Pullinger, J. D. J. Sng, X. Wang, T. F. Buck, F. J. Torres, J. J. Harrison, A. M. G. Colmant, J. Hobson-Peters, R. A. Hall, A. Tuplin, A. A. Khromykh

This study analyzes 3'UTRs of insect flaviviruses to identify novel xrRNAs involved in sfRNA biogenesis and provides insights into flavivirus evolution.

bioRxiv · Jun 23, 2021Microbiology

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

A. Slonchak, X. Wang, H. Chaggar, J. Aguado, M. Freney, K. Yan, F. J. Torres, A. A. Amarilla, R. Balea, J. D. J. Sng, Y. X. Setoh, N. Peng, D. Watterson, E. Wolvetang, A. Suhrbier, A. A. Khromykh

This study identifies how ZIKV sfRNA interacts with NS5 to inhibit STAT1 phosphorylation, promoting viral pathogenesis in placental and neural tissues.

bioRxiv · May 18, 2021Microbiology