Author

O. P. McGuinness

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Research Focus:metabolism & bioenergetics· 4 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

L. Lantier· 2 shared A. H. Hasty· 1 shared A. McDonald-Boyer· 1 shared A. S. Banks· 1 shared A. Thompson Gray· 1 shared B. Li· 1 shared C. H. Johnson· 1 shared C. Palmer· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPhysiology

L. Lantier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Insulin at the Intersection of Thermoregulation and Glucose Homeostasis

N. C. Winn, M. W. Schleh, J. N. Garcia, L. Lantier, O. P. McGuinness, J. A. Blair, A. H. Hasty, D. H. Wasserman

This study shows that thermoneutral temperature reduces energy expenditure and insulin-mediated glucose fluxes in mice, while insulin-independent glucose uptake in brown fat adjusts to temperature changes without compromising glucose homeostasis.

bioRxiv · Nov 17, 2023Physiology

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

J. K. Corrigan, D. Ramachandran, Y. He, C. Palmer, M. J. Jurczak, B. Li, R. H. Friedline, J. K. Kim, J. J. Ramsey, L. Lantier, O. P. McGuinness, A. S. Banks, Mouse Metabolic Phenotyping Center Energy Balance Working Group

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

eLife · May 1, 2020Peer-reviewedPhysiology

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

R. P. Ceddia, Z. Zurawski, A. Thompson Gray, F. Adegboye, A. McDonald-Boyer, F. Shi, D. Liu, J. Maldonado, J. Feng, Y. Li, S. Alford, J. E. Ayala, O. P. McGuinness, S. Collins, H. E. Hamm

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

bioRxiv · Apr 29, 2020 · PreprintPhysiology

Eating breakfast and avoiding the evening snack sustains lipid oxidation

K. P. Kelly, O. P. McGuinness, M. Buchowski, J. P. Hughey, H. Chen, J. Powers, T. Page, C. H. Johnson

This study shows that eating breakfast instead of an evening snack increases lipid oxidation in older adults, highlighting the impact of meal timing on metabolism.

bioRxiv · Jan 29, 2020Animal Behavior & Cognition