Author

I. Rothenaigner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:organoid / primary culture· 2 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Hadian· 5 shared K. Schorpp· 3 shared J. Tschuck· 2 shared S. Brandner· 2 shared A. Bessadok· 1 shared A. Biibosunov· 1 shared A. Czarna· 1 shared A. Dabrowska· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCell Biology

K. Hadian

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening

A. Ramani, G. Pasquini, N. Gerkau, O. S. Vinchure, E. Gabriel, I. Rothenaigner, S. Lin, N. Altinisk, D. Rathinam, A. Mirsaidi, O. Goureau, L. Ricci-Vitiani, G. Q. d'alessandris, R. Pallini, B. Wollnik, , J. Gopalakrishnan

This study develops a high-throughput method to generate reliable human brain organoids for modeling microcephaly, glioma invasion, and drug screening.

bioRxiv · Oct 29, 2023Cell Biology

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

J. Tschuck, V. Padmanabhan Nair, A. Galhoz, G. Ciceri, I. Rothenaigner, J. Tchieu, H.-M. Tai, B. R. Stockwell, L. Studer, M. P. Menden, M. Vincendeau, K. Hadian

This study shows that suppressing ferroptosis via antioxidants or vitamin A is necessary for proper neuronal development and laminar organization in cortical organoids.

bioRxiv · Apr 5, 2023 · PreprintCell Biology

CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting

K. Schorpp, A. Bessadok, A. Biibosunov, I. Rothenaigner, S. Strasser, T. Peng, K. Hadian

CellDeathPred uses deep learning on cell painting images to predict ferroptosis and apoptosis with 95% accuracy in human cells.

bioRxiv · Mar 14, 2023Cell Biology

Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis

J. Tschuck, L. Theilacker, I. Rothenaigner, S. A. Weiss, B. Akdogan, C. Mueller, R. Graf, S. Brandner, C. Puetz, T. Rieder, P. Schmitt-Kopplin, H. Zischka, K. Schorpp, K. Hadian

This study identifies FXR agonists that suppress ferroptosis by upregulating protective proteins, highlighting FXR's role in preventing lipid peroxidation and ferroptotic cell death.

bioRxiv · Oct 7, 2022 · PreprintCell Biology

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

V. Napolitano, A. Dabrowska, K. Schorpp, A. Mourao, E. Barreto-Duran, M. Benedyk, P. Botwina, S. Brandner, M. Bostock, Y. Chykunova, A. Czarna, G. Dubin, T. Frohlich, M. Hoelscher, M. Jedrysik, , K. Pyrc

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

bioRxiv · Mar 20, 2021Microbiology