Author

O. Eskiocak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Beyaz· 3 shared C. Chung· 2 shared A. Burr· 1 shared A. C. Poholek· 1 shared A. Erdemir· 1 shared A. Garipcan· 1 shared A. Kucukural· 1 shared A. Overacre-Delgoffe· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

S. Beyaz

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Author profile →

3 papers

Recent·Most cited

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

O. Eskiocak, S. Chowdhury, V. Shah, E. Nnuji-John, C. Chung, J. A. Boyer, A. S. Harris, J. Habel, M. Sadelain, S. Beyaz, C. Amor

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

bioRxiv · Mar 19, 2024 · PreprintCell Biology

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

A. Burr, J. Ji, K. Ozler, O. Eskiocak, B. Yueh, A. V. Menk, A. S. H. Costa, N. Rittenhouse, C. W. Marshall, P. Chiaranunt, L. Mullinax, A. Overacre-Delgoffe, V. S. Cooper, A. C. Poholek, G. M. Delgoffe, , T. Hand

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

bioRxiv · Aug 18, 2021 · PreprintImmunology

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

S. Beyaz, J. Roper, M. E. Xifaras, K. E. Bauer-Rowe, I. Ergin, L. Dohnalova, M. Biton, K. Shekar, H. Mou, O. Eskiocak, D. M. Ozata, C. Chung, K. Papciak, M. Almeqdadi, M. Fein, , O. H. Yilmaz

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

bioRxiv · Sep 5, 2020Cancer Biology