Author

J. Hildebrand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

C. Hall· 4 shared J. M. Murphy· 3 shared A. Jacobsen· 2 shared A. L. Samson· 2 shared I. Wicks· 2 shared J. Rickard· 2 shared J. Silke· 2 shared K. R. Martin· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

C. Hall

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Author profile →

5 papers

Recent·Most cited

An immunohistochemical atlas of necroptotic pathway expression

S. Chiou, A. Al-Ani, Y. Pan, K. Patel, I. Kong, L. Whitehead, A. Light, S. Young, M. Barrios, C. Sargeant, P. Rajasekhar, L. Zhu, A. Hempel, A. Lin, J. Rickard, , A. L. Samson

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

bioRxiv · Oct 31, 2023Cell Biology

IL-15 complex-induced IL-10 enhances Plasmodium-specific CD4+ Tfh differentiation and antibody production

M. Bravo, T. Dileepan, M. Dolan, J. Hildebrand, J. Wolford, S. E. Hamilton, A. E. Frosch, K. S. Burrack

This study shows that IL-15 complex treatment increases IL-10 in NK cells, which promotes Tfh differentiation and antibody production against Plasmodium, improving survival from reinfection.

bioRxiv · Oct 6, 2023 · PreprintImmunology

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

H. Tye, S. A. Conos, T. M. Djajawi, N. Abdoulkader, I. Y. Kong, H. L. Kaummon, V. K. Narayana, M. Speir, T. A. Gottschalk, J. Emery, D. S. Simpson, C. Hall, A. J. Vince, S. Russo, R. Crawley, , K. Lawlor

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

bioRxiv · Mar 14, 2023Immunology

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

bioRxiv · Sep 8, 2022 · PreprintImmunology

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

J. Hildebrand, M. Kauppi, I. Majewski, Z. Liu, A. Cox, S. Miyake, C. Hall, E. Petrie, M. Silk, M. Tanzer, S. Young, S. Garnish, J. Corbin, M. Stutz, P. Gangatirkar, , Venhoff

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

bioRxiv · May 15, 2019 · PreprintCell Biology