J. Horejs-Hoeck

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.

A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin

This study develops a humanized mouse model to study human cutaneous memory T cells in vivo, showing their functional profiles and responses to pathogens.

Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cells

This study identifies IDO1-kynurenine pathway activation as a novel mechanism by which HH-IL6 and GLI-STAT signaling promote immunosuppression in skin cancer, suggesting combination therapy targeting these pathways.

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma

This study shows that LamOVA, a hypoallergenic beta-glucan neoglycoconjugate, suppresses lung inflammation and reduces side effects in a mouse asthma model when delivered via laser-facilitated epicutaneous immunotherapy.