R. Weiss

Analog epigenetic memory revealed by targeted chromatin editing

This study reveals analog epigenetic memory through graded DNA methylation, showing its temporal stability and role in gene expression regulation.

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

Laser facilitated epicutaneous peptide immunization using dry patch technology

This study demonstrates that laser-assisted dry patch delivery of peptides with CpG-ODN1826 induces potent cytotoxic T cell responses in a mouse model.

Laser-facilitated epicutaneous immunization with SARS-CoV-2 spike protein induces ACE2 blocking antibodies in mice

Towards middle-up analysis of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by means of HPLC-MS

This paper develops a middle-up HPLC-MS workflow to profile subclass-specific N-glycosylation in murine polyclonal IgGs, revealing subclass and glycosylation shifts in immunized mice.

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization

Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

This study examines how structural stability of tropomyosins affects their endolysosomal degradation and T-cell reactivity across different invertebrate sources.

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma

This study shows that LamOVA, a hypoallergenic beta-glucan neoglycoconjugate, suppresses lung inflammation and reduces side effects in a mouse asthma model when delivered via laser-facilitated epicutaneous immunotherapy.

Mast cells and γδ T cells are largely dispensable for adaptive immune responses after laser-mediated epicutaneous immunization

This study shows that γδ T cells and mast cells are largely dispensable for adaptive immune responses after laser-mediated epicutaneous immunization, except for minor effects on IgG1 and effector T cells in mast cell-depleted mice.

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

This study investigates how Hedgehog signaling in skin cancer modulates immune cells and resistance to immunotherapy, identifying potential targets for combination treatments.