Author

J. Hsieh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Hakimi· 2 shared B. Nixon· 2 shared F. Kuo· 2 shared K. Capistrano· 2 shared M. Do· 2 shared M. Li· 2 shared M. Liu· 2 shared T. Chan· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

A. Hakimi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Subunit Communication within Dimeric SF1 DNA Helicases

B. Nguyen, J. Hsieh, C. J. Fischer, T. M. Lohman

This study shows that specific dimer interactions and ATPase activity in both subunits are required for helicase activity in E. coli Rep and UvrD, with subunit communication demonstrated through Trp fluorescence.

bioRxiv · Feb 20, 2024Biochemistry

Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy

J. Hsieh, K. Becklin, S. Givens, E. R. Komosa, J. E. Abrahante Llorens, F. Kamdar, B. S. Moriarity, B. R. Webber, B. N. Singh, B. M. Ogle

This study identifies early-stage ECM dysregulation in HCM caused by MYH7/MYH6 mutations using hiPSC-derived cardiomyocytes.

bioRxiv · Apr 5, 2022Bioengineering

A Capped Tudor Domain within a Core Subunit of the Sin3L/Rpd3L Histone Deacetylase Complex Binds Nucleic Acids

R. D. Marcum, J. Hsieh, M. Giljen, Y. Zhang, I. Radhakrishnan

The paper identifies a novel Tudor domain in the Sds3 subunit of the Sin3L/Rpd3L complex that binds nucleic acids, expanding the known functions of this HDAC complex.

bioRxiv · Aug 9, 2021Biochemistry

New Structural Insights into the Function of the Catalytically Active Human Taspase1

N. Nagaratnam, S. Delker, R. Jernigan, T. E. Edwards, J. Snider, D. Thifault, D. Williams, B. L. Nannenga, M. Stofega, L. Sambucetti, J. Hsieh, A. J. Flint, P. Fromme, J. M. Martin-Garcia

This study determines the crystal structure of catalytically active human Taspase1 and identifies a long helical domain essential for its enzymatic activity, suggesting it as a potential target for anticancer therapeutics.

bioRxiv · Nov 26, 2020Biochemistry

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

B. Nixon, F. Kuo, M. Liu, K. Capistrano, M. Do, R. Franklin, X. Wu, E. Kansler, R. Srivastava, T. Purohit, A. Sanchez, L. Vuong, C. Krishna, H. Morse, J. Hsieh, , M. Li

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

bioRxiv · Mar 12, 2020 · PreprintImmunology

TGFβ Suppresses Type 2 Immunity to Cancer

M. Liu, F. Kuo, K. Capistrano, D. Kang, B. Nixon, W. Shi, C. Chou, M. Do, S. Li, E. Stamatiades, Y. Chen, J. Hsieh, A. Hakimi, I. Taniuchi, T. Chan, M. Li

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

bioRxiv · Mar 4, 2020 · PreprintImmunology