Author

J. Koomen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Fang· 3 shared R. J. Gillies· 2 shared A. Chen· 1 shared A. El-Kenawi· 1 shared A. Karolak· 1 shared A. Keske· 1 shared A. Marusyk· 1 shared A. Riva· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

B. Fang

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4 papers

Recent·Most cited

Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer

K. Ross, G. Zhang, C. Akcora, Y. Lin, B. Fang, J. Koomen, E. Haura, M. Grimes

The paper uses machine learning to analyze PTM data from lung cancer cell lines, identifying functional modules and networks that reveal crosstalk between signaling pathways and metabolic processes in response to TKIs.

bioRxiv · Oct 28, 2022Cancer Biology

HDAC8-mediated inhibition of EP300 drives a neural crest-like transcriptional state that increases melanoma brain metastasis

M. F. Emmons, R. L. Bennett, A. Riva, C. Zhang, R. Macaulay, D. Dupere-Richer, B. Fang, E. Seto, J. Koomen, J. Li, A. Chen, P. Forsyth, J. Licht, K. S. M. Smalley

bioRxiv · Oct 12, 2022 · PreprintCancer Biology

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

M. Damaghi, S. Byrne, L. Xu, N. Tafreshi, B. Fang, J. Koomen, A. Karolak, T. Chen, J. Johnson, N. Gallant, A. Marusyk, R. J. Gillies

The paper identifies collagen production as an adaptation strategy in acidotic cancer cells, showing correlation with patient survival.

bioRxiv · Jul 24, 2019Cancer Biology