Author

K. K. Steiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. A. Needle· 2 shared J. C. Rathmell· 2 shared A. Christofides· 1 shared A. El-Kenawi· 1 shared A. H. Hasty· 1 shared A. Keske· 1 shared A. R. Patterson· 1 shared A. Sugiura· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

G. A. Needle

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Author profile →

3 papers

Recent·Most cited

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

A. R. Patterson, G. A. Needle, A. Sugiura, C. Chi, K. K. Steiner, E. L. Fisher, G. L. Robertson, C. Bodnya, J. G. Markle, V. Gama, J. C. Rathmell

The paper identifies functional overlap between inborn errors of immunity and metabolism genes, revealing immunometabolic vulnerabilities in T cells.

bioRxiv · Jan 24, 2023 · PreprintImmunology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology