Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS
S. Mosegaard, K. Twayana, S. Denis, J. Kroon, B. V. Schomakers, M. van Weeghel, R. Houtkooper, R. K. J. Olsen, C. K. Holm
This study shows that mutations in ETFDH and ACADVL, which are involved in long-chain fatty acid oxidation, impair inflammatory responses to LPS by reducing TLR4 expression and cytokine production.
FASEB BioAdvances · Sep 1, 2024Peer-reviewedImmunology