Author

M. van Weeghel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Physiology· 2 Immunology· 1

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Research Focus:cell type annotation· 7 Approach:experimental assay· 6 Assay:metabolomics· 6 Assay:proteomics· 4 Organism:C. elegans· 3 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

B. V. Schomakers· 3 shared G. E. Janssens· 3 shared R. Houtkooper· 3 shared A. W. Gao· 2 shared F. M. Vaz· 2 shared J. W. Borst· 2 shared R. H. Houtkooper· 2 shared R. L. Smith· 2 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

B. V. Schomakers

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS

S. Mosegaard, K. Twayana, S. Denis, J. Kroon, B. V. Schomakers, M. van Weeghel, R. Houtkooper, R. K. J. Olsen, C. K. Holm

This study shows that mutations in ETFDH and ACADVL, which are involved in long-chain fatty acid oxidation, impair inflammatory responses to LPS by reducing TLR4 expression and cytokine production.

FASEB BioAdvances · Sep 1, 2024Peer-reviewedImmunology

Human ovarian ageing is characterized by oxidative damage and mitochondrial dysfunction

M. A. J. Smits, B. V. Schomakers, M. van Weeghel, E. J. M. Wever, R. C. I. Wust, F. Dijk, G. E. Janssens, M. Goddijn, S. Mastenbroek, R. Houtkooper, G. Hamer

This study identifies oxidative damage and mitochondrial dysfunction in human oocytes during ovarian ageing using immunofluorescence, metabolomics, and lipidomics.

bioRxiv · Jan 31, 2023Cell Biology

Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse

E. Diekman, M. van Weeghel, M. Suarez-Farinas, C. Argmann, P. Ranea-Robles, R. Wanders, G. Visser, I. van der Made, E. Creemers, S. Houten

This study examines the effects of dietary restriction on plasma metabolites and cardiac function in LCAD KO mice, finding minimal impact on metabolites and no cardiac remodeling.

bioRxiv · Dec 3, 2020Physiology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Metabolomics and lipidomics in C. elegans using a single sample preparation

M. Molenaars, B. V. Schomakers, H. L. Elfrink, A. W. Gao, M. A. T. Vervaart, M. L. Pras-Raves, A. C. Luyf, R. L. Smith, M. G. Sterken, J. E. Kammenga, A. H. C. van Kampen, G. E. Janssens, F. M. Vaz, M. van Weeghel, R. H. Houtkooper

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

bioRxiv · Jul 6, 2020Biochemistry

Hypoxia-inducible lipid droplet-associated interacts with DGAT1 and promotes lipid storage in hepatocytes

M. de la Rosa Rodriguez, A. Gemmink, M. van Weeghel, M. L. Aoun, R. Singh, J. W. Borst, S. Kersten, C. Warnecke

This study identifies HILPDA as a protein that interacts with DGAT1 and enhances lipid storage in hepatocytes by promoting triglyceride synthesis.

bioRxiv · Feb 26, 2020Biochemistry

HILPDA uncouples lipid storage in adipose tissue macrophages from inflammation and metabolic dysregulation

X. A. M. H. van Dierendonck, M. A. de la Rosa Rodriguez, A. Georgiadi, F. Mattijssen, W. Dijk, M. van Weeghel, R. Singh, J. W. Borst, R. Stienstra, S. Kersten

This study shows that HILPDA deficiency reduces lipid storage in adipose tissue macrophages without affecting inflammation or metabolic issues in obese mice.

bioRxiv · Mar 5, 2019Physiology

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

A. Gao, R. Smith, M. Van Weeghel, R. Kamble, R. Houtkooper

This study identifies shared metabolic pathways and signatures of longevity in C. elegans by integrating transcriptomics and metabolomics data from IIS and CR models.

bioRxiv · Nov 21, 2017Biochemistry