Author

Y. A. Senis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. J. Barr· 1 shared A. Jouppila· 1 shared A. L. Dalby· 1 shared A. Mazharian· 1 shared C. Geh· 1 shared C. W. Smith· 1 shared D. J. Ogg· 1 shared D. Semeniak· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. J. Barr

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Analysis of Preplatelets and Their Barbell Platelet Derivatives by Imaging Flow Cytometry

S. Kemble, A. L. Dalby, G. C. Lowe, P. L. Nicolson, S. P. Watson, Y. A. Senis, S. G. Thomas, P. Harrison

This study uses imaging flow cytometry and microscopy to show that preplatelets and barbell platelets are immature structures that transform into mature platelets in mice and humans.

bioRxiv · Jul 30, 2021Cell Biology

Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

J. C. Yam-Puc, L. Zhang, R. A. Maqueda-Alfaro, L. Garcia-Ibanez, Y. Zhang, J. Davies, Y. A. Senis, M. Snaith, K.-M. Toellner

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

bioRxiv · Jul 29, 2020Immunology

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

T. Vögtle, S. Sharma, J. Mori, Z. Nagy, D. Semeniak, M. J. Geer, C. W. Smith, J. Lane, S. Pollack, R. Lassila, A. Jouppila, A. J. Barr, D. J. Ogg, T. D. Howard, H. J. McMiken, , Y. A. Senis

This study identifies heparan sulfate as a critical regulator of G6b-B, showing it inhibits platelet and megakaryocyte function through Shp1/Shp2 signaling.

bioRxiv · Mar 25, 2019Biochemistry