Author

R. E. Diaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. S. Fraser· 3 shared R. M. Locksley· 3 shared G. J. Correy· 2 shared I. D. Young· 2 shared S. J. Van Dyken· 2 shared A. Aimon· 1 shared A. C. Thwin· 1 shared A. Dias· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

J. S. Fraser

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Author profile →

4 papers

Recent·Most cited

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

R. E. Diaz, A. K. Ecker, G. J. Correy, P. Asthana, I. D. Young, B. Faust, M. C. Thompson, I. B. Seiple, S. J. Van Dyken, R. M. Locksley, J. S. Fraser

This study characterizes the pH-specific enzymatic activity and ligand binding of mouse AMCase using structural and computational methods, revealing dual activity optima at pH 2 and 7.

bioRxiv · Jun 3, 2023Biochemistry

Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

R. R. Ricardo-Gonzalez, M. E. Kotas, I. Tenvooren, D. M. Marquez, M. S. Fassett, J. Lee, S. G. Daniel, K. Bittinger, R. E. Diaz, J. S. Fraser, K. M. Ansel, M. H. Spitzer, H.-E. Liang, R. M. Locksley

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

bioRxiv · Mar 29, 2021 · PreprintImmunology

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

M. Schuller, G. J. Correy, S. Gahbauer, D. Fearon, T. Wu, R. E. Diaz, I. D. Young, L. Carvalho Martins, D. H. Smith, U. Schulze-Gahmen, T. W. Owens, I. Deshpande, G. E. Merz, A. C. Thwin, J. T. Biel, , Smi

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

bioRxiv · Nov 24, 2020Biochemistry

Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates

B. A. Barad, L. Liu, R. E. Diaz, R. Basilio, S. J. Van Dyken, R. M. Locksley, J. S. Fraser

This study identifies mutations that enhance chitinase activity on oligomeric substrates but not crystalline chitin, highlighting the importance of using physiologically relevant substrates in enzyme engineering.

bioRxiv · Oct 17, 2019 · PreprintBiochemistry