J. M. Jacobs

A Ralstonia solanacearum type III effector alters the actin and microtubule cytoskeleton to promote bacterial virulence in plants

This study shows that the Ralstonia solanacearum type III effector RipUK60 disrupts plant cytoskeleton organization to enhance bacterial virulence.

Allelic variations in a serine protease effector within Clavibacter michiganensis populations determine pathogen host range

This study identifies allelic variation in the chpG effector gene as a key determinant of host range plasticity in Clavibacter michiganensis populations.

Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade episome reduction

The paper tracks a 2022 plant pathogen outbreak, revealing a recent genome reduction event in Xanthomonas hortorum through real-time sequencing and historical isolate analysis.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Coupling microdroplet-based sample preparation, multiplexed isobaric labeling, and nanoflow peptide fractionation for deep proteome profiling of tissue microenvironment

This paper develops a combined proteomic workflow to enable deep spatial proteome profiling of small tissue samples, achieving over 5,000 protein quantifications from a human pancreatic tissue pixel.

Novel genetic traits in Xanthomonas unveiled by the complete genome sequencing of three clade-1 xanthomonads

This study sequenced three novel clade-1 xanthomonads using long-read sequencing, revealing unique genetic traits and potential pathogenic mechanisms.

Development of genome-driven, lifestyle-informed primers for identification of the cereal infecting pathogens Xanthomonas translucens pathovars undulosa and translucens.

The paper develops a multiplex PCR method to distinguish between two pathovars of Xanthomonas translucens using genome differences, validated across multiple strains.

The Mycobacterium tuberculosis protein O-phosphorylation landscape

This study identifies the O-phosphorylation landscape in Mycobacterium tuberculosis, revealing its widespread impact on the proteome and gene regulation.

Metagenomic sequencing for rapid identification of Xylella fastidiosa from leaf samples

This paper develops a metagenomics pipeline for rapid, accurate identification of Xylella fastidiosa from leaf samples, detecting subspecies and strains at low concentrations.

Repeated gain and loss of a single gene modulates the evolution of vascular pathogen lifestyles

The paper shows that the gene cbsA acts as a switch for vascular vs. non-vascular pathogenesis in bacteria, with its presence and absence linked to lifestyle evolution.