Author

M. Sadilek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:metabolism & bioenergetics· 4 Organism:mouse· 4 Organism:human· 3 Assay:metabolomics· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. B. Hurley· 5 shared B. M. Robbings· 4 shared D. T. Hass· 4 shared C. M. Bisbach· 3 shared I. R. Sweet· 3 shared A. L. Engel· 2 shared A. M. Rountree· 2 shared J. D. Linton· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersBiochemistry

J. B. Hurley

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Author profile →

6 papers

Recent·Most cited

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

D. T. Hass, K. Pandey, A. L. Engel, N. Horton, B. M. Robbings, R. Lim, M. Sadilek, Q. Zhang, G. A. Autterson, J. M. Miller, J. R. Chao, J. B. Hurley

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

C. J. A. Leonen, M. Shimada, C. E. Weller, T. Nakadai, P. L. Hsu, P. M. M. Shelton, M. Sadilek, N. Zheng, B. Roeder, C. Chatterjee

This study shows that sumoylation of H4K12 inhibits p300-mediated transcription and H3K4 methylation in vitro.

bioRxiv · Apr 8, 2021Biochemistry

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry

Succinate metabolism uncouples retinal pigment epithelium mitochondria

D. T. Hass, C. M. Bisbach, B. M. Robbings, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

bioRxiv · Feb 10, 2021 · PreprintBiochemistry

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

C. M. Bisbach, D. T. Hass, B. M. Robbings, A. M. Rountree, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

bioRxiv · Jan 17, 2020Biochemistry

Biochemical Adaptations Of The Retina And Retinal Pigment Epithelium Support A Metabolic Ecosystem In The Vertebrate Eye

M. A. Kanow, M. M. Giarmarco, C. Jankowski, K. Tsantilas, A. L. Engel, J. Du, J. D. Linton, C. C. Farnsworth, S. R. Sloat, K. J. Lindsay, E. D. Parker, S. E. Brockerhoff, M. Sadilek, J. R. Chao, J. B. Hurley

The paper presents a model of retinal metabolism showing glucose is converted to lactate by photoreceptors and used by retinal pigment epithelium and Muller glial cells, with implications for retinal disease and therapy.

bioRxiv · May 29, 2017Biochemistry