Author

B. M. Robbings

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:metabolism & bioenergetics· 4 Organism:mouse· 4 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. B. Hurley· 6 shared D. T. Hass· 5 shared C. M. Bisbach· 4 shared I. R. Sweet· 4 shared M. Sadilek· 4 shared A. M. Rountree· 2 shared K. A. Tsantilas· 2 shared K. Pandey· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersBiochemistry

J. B. Hurley

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Author profile →

7 papers

Recent·Most cited

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

D. T. Hass, K. Pandey, A. L. Engel, N. Horton, B. M. Robbings, R. Lim, M. Sadilek, Q. Zhang, G. A. Autterson, J. M. Miller, J. R. Chao, J. B. Hurley

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

D. T. Hass, E. Giering, J. Y. S. Han, C. M. Bisbach, K. Pandey, B. M. Robbings, T. O. Mundinger, N. D. Nolan, S. H. Tsang, N. J. Philp, N. S. Peachey, J. B. Hurley

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

bioRxiv · Apr 10, 2023 · PreprintBiochemistry

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry

Fluidics System for Resolving Concentration-Dependent Effects of Dissolved Gases on Tissue Metabolism

I. R. Sweet, J. B. Hurley, V. Kamat, B. M. Robbings, K. P. Bube, S.-R. Jung, J. Kelly

This paper introduces a fluidics system to study how dissolved gases affect tissue metabolism and function, revealing new insights into oxygen consumption and hydrogen sulfide effects on insulin secretion.

bioRxiv · Mar 7, 2021Cell Biology

Succinate metabolism uncouples retinal pigment epithelium mitochondria

D. T. Hass, C. M. Bisbach, B. M. Robbings, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

bioRxiv · Feb 10, 2021 · PreprintBiochemistry

Daily mitochondrial dynamics in cone photoreceptors

M. M. Giarmarco, D. C. Brock, B. M. Robbings, W. M. Cleghorn, K. A. Tsantilas, K. C. Kuch, W. Ge, K. M. Rutter, E. D. Parker, S. E. Brockerhoff

The paper examines daily mitochondrial dynamics in zebrafish cone photoreceptors, finding increased mitochondrial biogenesis at night and structural changes during the day.

bioRxiv · Apr 10, 2020Cell Biology

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

C. M. Bisbach, D. T. Hass, B. M. Robbings, A. M. Rountree, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

bioRxiv · Jan 17, 2020Biochemistry