Author

M. M. Szewczyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

C. H. Arrowsmith· 3 shared D. Barsyte-Lovejoy· 3 shared D. Dilworth· 2 shared M. D. Minden· 2 shared V. Vu· 2 shared A. Hutchinson· 1 shared A. J. R. Heck· 1 shared A. Lemak· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

C. H. Arrowsmith

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Author profile →

4 papers

Recent·Most cited

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations

M. Alqazzaz, G. Luciani, V. Vu, R. M. Machado, M. M. Szewczyk, E. C. Adamson, S. Cheon, C. Arrowsmith, M. D. Minden, D. Barsyte-Lovejoy

This study identifies epigenetic vulnerabilities in AML and MDS/MPN with EZH2 mutations, showing increased sensitivity to EZH2 and EED inhibitors and upregulation of cell death pathways.

bioRxiv · Nov 20, 2023Cancer Biology

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. M. Szewczyk, G. M. Luciani, V. Vu, A. Murison, D. Dilworth, M. Lupien, C. H. Arrowsmith, M. D. Minden, D. Barsyte-Lovejoy

This study shows PRMT5 regulates ATF4 splicing and oxidative stress response in AML, with EVI1-high cells depending on PRMT5 for redox balance.

bioRxiv · Feb 2, 2022Cancer Biology

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

bioRxiv · Apr 2, 2021Biochemistry

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

M. M. Szewczyk, Y. Ishikawa, S. Organ, N. Sakai, F. Li, S. Ackloo, M. S. Eram, D. Dilworth, H. Fukushi, R. Harding, C. C. dela Sena, T. Sugo, K. Hayashi, D. Macleod, C. Zepeda, , D. Barsyte-Lovejoy

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

bioRxiv · Mar 15, 2019Biochemistry