J. Pernier

The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly

This study investigates how α-catenin, vinculin, and VASP work together in a complex to regulate actin assembly during adherens junction formation.

Talin and vinculin combine their activities to trigger actin assembly

This study shows that talin and vinculin work together to enhance actin assembly through a sequential mechanism involving nucleation, capping, and elongation.

Talin and kindlin cooperate to control the density of integrin clusters.

This study shows that talin and kindlin work together to control integrin cluster density, with kindlin enhancing talin and integrin density and facilitating cluster segregation by actomyosin.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions

The paper investigates how IRSp53 clustering regulates filopodia initiation by recruiting VASP to form actin-based membrane protrusions.

Myosin 1b Flattens and Prunes Branched Actin Filaments.

This paper shows myosin 1b flattens and breaks Arp2/3-dependent actin branches and reduces new branch formation using in vitro assays and TIRF microscopy.

A new actin depolymerase: a Myosin 1 motor

This study identifies myosin1b as a new actin depolymerase that enhances depolymerization at the barbed end through unique interactions, distinct from myosin II.