J. R. Knudsen

Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle

This study shows that microtubule disruption impairs GLUT4 trafficking in skeletal muscle, contributing to insulin resistance.

The role of group I p21-activated kinases in contraction-stimulated skeletal muscle glucose transport

This study investigates the role of group I p21-activated kinases (PAKs) in contraction-stimulated glucose transport in skeletal muscle, finding that PAK2, but not PAK1, contributes to this process in EDL muscle.

Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)-2, but not PAK1, in mouse skeletal muscle

This study investigates the role of PAK1 and PAK2 in insulin-stimulated glucose uptake in mouse skeletal muscle, finding that PAK2, not PAK1, contributes to this process.

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.

NADPH-oxidase 2 is required for molecular adaptations to high-intensity interval training in skeletal muscle.

This study shows that NOX2 is necessary for skeletal muscle adaptations to high-intensity interval training, including antioxidant defense and mitochondrial changes.