S. H. Raun

Pantothenate Kinase 4 controls efficient skeletal muscle energy substrate metabolism via acetyl-CoA

This study identifies PanK4 as a regulator of skeletal muscle energy metabolism, showing its role in acetyl-CoA regulation and metabolic flexibility.

Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle

This study shows that microtubule disruption impairs GLUT4 trafficking in skeletal muscle, contributing to insulin resistance.

Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type specific manner

This study investigates how cancer affects insulin signaling and glucose transport in different muscle types, finding muscle-specific impairments in insulin response and signaling pathways.

Breast cancer-secreted factors induce atrophy and reduce basal and insulinstimulated glucose uptake by inhibiting Rac1 activation in rat myotubes

This study shows breast cancer-secreted factors reduce glucose uptake in muscle by inhibiting Rac1 activation and inducing inflammation.

Housing temperature influences exercise training adaptations in mice

This study shows that housing mice at thermoneutral temperatures reduces exercise training benefits in metabolic parameters and tissue adaptations.

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.

NADPH-oxidase 2 is required for molecular adaptations to high-intensity interval training in skeletal muscle.

This study shows that NOX2 is necessary for skeletal muscle adaptations to high-intensity interval training, including antioxidant defense and mitochondrial changes.