Author

R. Holmdahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1

Frequent Co-Authors

A. A. Saei· 2 shared C. Dahlgren· 2 shared C. Henriquez-Olguin· 2 shared H. Forsman· 2 shared H. Gharibi· 2 shared J. R. Knudsen· 2 shared P. Olofsson· 2 shared R. A. Zubarev· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. A. Saei

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Author profile →

6 papers

Recent·Most cited

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

A. A. Saei, A. Lundin, H. Lyu, H. Gharibi, H. Luo, J. Teppo, X. Zhang, M. Gaetani, A. Vegvari, R. Holmdahl, S. P. Gygi, R. A. Zubarev

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

bioRxiv · Aug 31, 2023Biochemistry

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

J. James, Y. Chen, C. Hernandez, F. Forster, M. Dagnell, Q. Cheng, A. A. Saei, H. Gharibi, G. F. Lahore, A. Astrand, R. Malhotra, B. Malissen, R. A. Zubarev, E. Arner, R. Holmdahl

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

bioRxiv · Dec 2, 2021 · PreprintImmunology

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

S. Lind, R. Holmdahl, P. Olofsson, C. Dahlgren, H. Forsman

This study identifies a novel FPR1 agonist, RE, that shows biased signaling and functional selectivity in human neutrophils, potentially useful for anti-inflammatory therapeutics.

bioRxiv · May 20, 2020Cell Biology

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

C. Henriquez-Olguin, J. R. Knudsen, S. H. Raun, Z. Li, E. Dalbram, J. T. Treebak, L. Sylow, R. Holmdahl, E. A. Richter, E. Jaimovich, T. E. Jensen

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.

bioRxiv · May 23, 2019Physiology

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949

S. Lind, M. Sundqvist, R. Holmdahl, C. Dahlgren, H. Forsman, P. Olofsson

This study characterizes Act-389949, a FPR2 agonist, showing it induces neutrophil signaling and chemotaxis comparable to WKYMVM, with increased stability against oxidation.

bioRxiv · Mar 8, 2019Pharmacology & Toxicology

NADPH-oxidase 2 is required for molecular adaptations to high-intensity interval training in skeletal muscle.

C. Henriquez-Olguin, L. Baghersad Renani, L. Arab-Ceschia, S. H. Raun, A. Bhatia, Z. Li, J. R. Knudsen, R. Holmdahl, T. Jensen

This study shows that NOX2 is necessary for skeletal muscle adaptations to high-intensity interval training, including antioxidant defense and mitochondrial changes.

bioRxiv · Feb 6, 2019Physiology