L. Sylow

Pantothenate Kinase 4 controls efficient skeletal muscle energy substrate metabolism via acetyl-CoA

This study identifies PanK4 as a regulator of skeletal muscle energy metabolism, showing its role in acetyl-CoA regulation and metabolic flexibility.

Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type specific manner

This study investigates how cancer affects insulin signaling and glucose transport in different muscle types, finding muscle-specific impairments in insulin response and signaling pathways.

The role of group I p21-activated kinases in contraction-stimulated skeletal muscle glucose transport

This study investigates the role of group I p21-activated kinases (PAKs) in contraction-stimulated glucose transport in skeletal muscle, finding that PAK2, but not PAK1, contributes to this process in EDL muscle.

Breast cancer-secreted factors induce atrophy and reduce basal and insulinstimulated glucose uptake by inhibiting Rac1 activation in rat myotubes

This study shows breast cancer-secreted factors reduce glucose uptake in muscle by inhibiting Rac1 activation and inducing inflammation.

Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

This study shows cancer reduces insulin-stimulated glucose uptake in muscle and adipose tissue and impairs muscle microvascular perfusion in mice.

Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)-2, but not PAK1, in mouse skeletal muscle

This study investigates the role of PAK1 and PAK2 in insulin-stimulated glucose uptake in mouse skeletal muscle, finding that PAK2, not PAK1, contributes to this process.

Housing temperature influences exercise training adaptations in mice

This study shows that housing mice at thermoneutral temperatures reduces exercise training benefits in metabolic parameters and tissue adaptations.

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.