J. M. Schrader

Sinorhizobium meliloti BR-bodies promote fitness during host colonization

This study shows that BR-bodies in Sinorhizobium meliloti enhance mRNA decay efficiency and symbiotic fitness during host colonization.

Caulobacter crescentus RNase E condensation contributes to autoregulation and fitness

This study shows that RNase E autoregulation in Caulobacter crescentus involves phase-separation and 5 UTR cleavage, enhancing fitness through proper mRNA decay control.

The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions

The paper identifies 111 proteins enriched in bacterial RNP bodies (BR-bodies) and shows they form a complex network of protein-protein and protein-RNA interactions that regulate BR-body phase separation and RNA processing.

Initiator AUGs are discriminated from Elongator AUGs predominantly through mRNA accessibility in C. crescentus

The paper investigates how mRNA accessibility distinguishes initiator AUGs from elongator AUGs in C. crescentus by analyzing Shine-Dalgarno site function and RNA secondary structures.

RNase E biomolecular condensates stimulate PNPase activity

This study shows RNase E biomolecular condensates enhance PNPase activity, accelerating RNA decay and shaping the transcriptome.

Rif-Correct, a software tool for bacterial mRNA half-life estimation

Rif-Correct improves mRNA half-life estimation in Rif-seq data by accounting for transcriptional runoff using transcriptome models.

BR-bodies provide selectively permeable condensates that stimulate mRNA decay and prevent release of decay intermediates

The paper identifies RNA substrates of BR-bodies and shows they stimulate mRNA decay while preventing toxic intermediates.

Global transcriptome analysis of the Myxococcus xanthus multicellular developmental program

This study uses RNA-Seq to analyze the global transcriptome of Myxococcus xanthus during its multicellular developmental program, revealing gene expression patterns and regulatory networks.

Absolute measurements of mRNA translation in C. crescentus reveal important fitness costs of vitamin B12 scavenging

The paper measures mRNA translation in C. crescentus using ribosome profiling, finding that B12-related genes account for ~4.5% of protein synthesis and reveal fitness costs of B12 scavenging.

Spatial organization and dynamics of RNase E and ribosomes in Caulobacter crescentus

This study uses microscopy to show RNase E and ribosomes are spatially organized in Caulobacter crescentus, with clustering linked to RNA availability and rRNA gene location.