J. Shen

This paper introduces a continuous constant pH molecular dynamics method to simulate proton-coupled conformational dynamics of transmembrane proteins.

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.

This study presents two cryo-EM structures of human KCC1, revealing its inward-open and outward-open states and the mechanism of inhibition by a small molecule.

This study calculates pKa values and assesses proton-coupled conformational dynamics of SARS-CoV-2, SARS-CoV, and MERS-CoV PLpros to inform the design of broad-spectrum antiviral inhibitors.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.

This meta-analysis compares oncologic outcomes of T1 glottic carcinoma treated with transoral laser surgery or linear accelerator radiotherapy, finding better overall survival and laryngeal preservation with surgery.

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

The paper was withdrawn due to the authors no longer supporting some conclusions.

This study shows that glycyrrhizic acid improves cognitive function in aged mice by enhancing T and B cell proliferation and blood perfusion.

This study identifies autoinhibitory mechanisms in Mtf1 and TFB2M where the C-tail region regulates DNA binding activity through intramolecular interactions, which are relieved by RNA polymerase interaction.

This study presents the structure of primate ferroportin and elucidates its mechanism of iron transport and regulation by hepcidin.

This study identifies Myosin-7B and SLC35B2 as critical regulators of α-Synuclein fibril endocytosis, revealing a distinct pathway involving HSPG interactions and actin dynamics.

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

This study identifies distinct molecular profiles in Hispanic/Latino gastric cancer patients, including a high rate of CDH1 germline mutations linked to aggressive clinical outcomes.

This study uses genomics to determine the geographical origins of ancient butterfly specimens, resolving long-standing taxonomic disputes and demonstrating the utility of ancient DNA in species delineation.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study identifies proteomic and metabolomic changes in Escherichia coli mediated by mcr-1, showing altered lipid metabolism and efflux pump activity contribute to colistin resistance.

This study shows that B1a cells reduce liver inflammation and fibrosis in Schistosoma japonicum infection by secreting IL-10, which suppresses monocyte infiltration and inflammatory cytokines.

This study shows PARP inhibitors trigger an immune response via the STING pathway, enhancing immune checkpoint blockade efficacy regardless of BRCA mutations.