Author

J. Unruh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 4 Organism:yeast· 4 Assay:proteomics· 3 Approach:biophysical modeling· 2 Organism:human· 2

Frequent Co-Authors

Z. Yu· 3 shared J. J. Lange· 2 shared J. M. Varberg· 2 shared S. E. Smith· 2 shared S. Jaspersen· 2 shared S. L. Jaspersen· 2 shared A. A. Khan· 1 shared A. J. Bestul· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

Z. Yu

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Author profile →

7 papers

Recent·Most cited

Defining a core configuration for human centromeres during mitosis

A. S. Gupta, C. Seidel, D. Tsuchiya, S. A. McKinney, Z. Yu, S. E. Smith, J. Unruh, J. Gerton

The paper uses ChIP-seq and microscopy to determine the 3D organization of centromere components, revealing a core configuration that explains how centromeres function during mitosis.

bioRxiv · May 10, 2023 · PreprintCell Biology

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

X. Liu, Y. Zhang, Z. Wen, Y. Hao, C. Banks, J. J. Lange, J. Cesare, S. Bhattacharya, B. Slaughter, J. Unruh, L. Florens, J. Workman, M. Washburn

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

bioRxiv · Jan 31, 2023Biochemistry

A nucleation barrier spring-loads the CBM signalosome for binary activation

A. Rodriguez Gama, T. Miller, J. J. Lange, J. Unruh, R. Halfmann

The paper investigates the CBM signalosome's binary activation mechanism, showing that BCL10's nucleation barrier stores energy for rapid NF-κB activation upon stimulation.

bioRxiv · Jan 28, 2022Cell Biology

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

C. Akey, D. Singh, C. Ouch, I. Echeverria, I. Nudelman, J. M. Varberg, Z. Yu, F. Fang, Y. Shi, J. Wang, D. Saltzberg, K. Song, C. Xu, J. Gumbart, S. Suslov, , M. Rout

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

bioRxiv · Oct 29, 2021Biophysics

Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

J. M. Varberg, J. Unruh, A. J. Bestul, A. A. Khan, S. Jaspersen

This study quantifies NPC density and distribution in S. pombe nuclei using structured illumination microscopy, revealing NPC exclusion around the nucleolus and SPB and its dependence on Lem2-mediated centromere tethering.

bioRxiv · Aug 11, 2021Cell Biology

Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase

M. Geymonat, Q. Peng, Z. Guo, Z. Yu, J. Unruh, S. Jaspersen, M. Segal

The paper shows CDK enforces Spc72 asymmetric docking and regulates nucleation site balance in yeast SPB duplication.

bioRxiv · May 22, 2020Cell Biology

Asi1 regulates the distribution of proteins at the inner nuclear membrane in Saccharomyces cerevisiae

C. J. Smoyer, S. E. Smith, S. McCroskey, J. Unruh, S. L. Jaspersen

This study shows Asi1 regulates INM protein distribution by removing mis-targeted proteins and controlling native components like Pom33 through ubiquitination.

bioRxiv · Oct 14, 2018Cell Biology