Author

H. Blanc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:Arabidopsis· 6 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 4 Organism:Drosophila· 3 Assay:bulk RNA-seq· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2

Frequent Co-Authors

M.-C. Saleh· 8 shared L. Frangeul· 7 shared L. Lambrechts· 3 shared V. Mongelli· 3 shared Y. Suzuki· 3 shared A. B. Crist· 2 shared A. Baidaliuk· 2 shared A. Henrion-Lacritick· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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8 shared papersMicrobiology

M.-C. Saleh

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Viral infection disrupts intestinal homeostasis via Sting-dependent NF-kB signaling

J. C. Nigg, H. Blanc, L. Frangeul, V. Mongelli, X. Godron, A. J. Bardin, M.-C. Saleh

This study shows that viral infection disrupts intestinal homeostasis in Drosophila by activating Sting-dependent NF-kB signaling, leading to ISC proliferation and reduced lifespan.

bioRxiv · Nov 16, 2023 · PreprintMicrobiology

Challenges in the Biotechnological Implementation of Oral RNA Interference as an Antiviral Strategy in Aedes aegypti

O. Romoli, A. Henrion-Lacritick, H. Blanc, L. Frangeul, M. C. Saleh

This study investigates the effectiveness of oral RNA interference in Aedes aegypti mosquitoes to combat Zika and chikungunya viruses, finding limited success with bacterial dsRNA delivery but some effect with direct dsRNA injection.

bioRxiv · Nov 5, 2023 · PreprintMicrobiology

Hsc70-4 mediates internalization of environmental dsRNA at the surface of Drosophila S2 cells

S. J. Fletcher, L. Tome-Poderti, V. Mongelli, L. Frangeul, H. Blanc, Y. Verdier, J. Vinh, M.-C. Saleh

The paper identifies Hsc70-4 as a cell surface protein that mediates dsRNA internalization in Drosophila S2 cells, which is crucial for RNAi-based pest control.

bioRxiv · Mar 11, 2023 · PreprintCell Biology

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti

S. H. Merkling, A. B. Crist, A. Henrion-Lacritick, L. Frangeul, V. Gausson, H. Blanc, A. Baidaliuk, M.-C. Saleh, L. Lambrechts

This study investigates the role of Dicer2 in arbovirus transmission by Aedes aegypti, finding it affects early viral replication and mortality but not overall vector competence.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

F. Roesch, C. Cereghino, L. Carrau, A. Hardy, H. Ribeiro-Filho, A. Henrion Lacritick, C. Koh, J. Marano, T. A. Bates, P. Rai, C. Chuong, S. Akter, T. Vallet, H. Blanc, T. Elliot, , J. Weger-Lucarelli

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

bioRxiv · Apr 5, 2022 · PreprintMicrobiology

Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster

V. Mongelli, S. Lequime, A. Kousathanas, V. Gausson, H. Blanc, L. Quintana-Murci, S. F. Elena, M.-C. Saleh

This study shows that innate immune pathways in Drosophila constrain RNA virus evolution by reducing genetic diversity and virulence when disrupted.

bioRxiv · Jul 16, 2021Evolutionary Biology

Differential small RNA responses against co-infecting insect-specific viruses in Aedes albopictus mosquitoes

L. Frangeul, H. Blanc, M.-C. Saleh, Y. Suzuki

This study examines small RNA responses to co-infecting insect-specific viruses in male and female Aedes albopictus mosquitoes, revealing virus-specific small RNA profiles and sex-dependent antiviral mechanisms.

Viruses · Apr 21, 2020Peer-reviewedMicrobiology

Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries

Y. Suzuki, A. Baidaliuk, P. Miesen, L. Frangeul, A. B. Crist, S. H. Merkling, A. Fontaine, S. Lequime, I. Moltini-Conclois, H. Blanc, R. P. van Rij, L. Lambrechts, M.-C. Saleh

The paper shows that a non-retroviral EVE in Aedes aegypti limits replication of its cognate virus, CFAV, through piRNA-mediated antiviral activity in ovaries.

bioRxiv · Mar 28, 2020Microbiology

Uncovering The Repertoire Of Endogenous Flaviviral Elements In Aedes Mosquito Genomes

Y. Suzuki, L. Frangeul, L. B. Dickson, H. Blanc, Y. Verdier, J. Vinh, L. Lambrechts, M.-C. Saleh

This study identifies and characterizes endogenous flaviviral elements in Aedes mosquito genomes, revealing structural diversity and RNA-based functions.

bioRxiv · Apr 4, 2017Microbiology