Author

J. W. Opzoomer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:wet-lab / biochemical assay· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. R. Withers· 2 shared D. Sosnowska· 2 shared I. Dean· 2 shared J. Caron· 2 shared J. E. Anstee· 2 shared J. N. Arnold· 2 shared S. Kordasti· 2 shared T. Lawrence· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. R. Withers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis

J. W. Opzoomer, R. O'Sullivan, J. Sufi, R. R. Madsen, X. Qin, E. Basiarz, C. J. Tape

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

J. E. Anstee, J. W. Opzoomer, I. Dean, H. P. Muller, M. Bahri, K. Liakath-Ali, Z. Liu, D. Choy, J. Caron, D. Sosnowska, R. Beatson, T. Muliaditan, Z. An, C. E. Gillett, G. Lan, , J. N. Arnold

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

bioRxiv · Feb 3, 2022Cancer Biology

Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

J. W. Opzoomer, J. E. Anstee, I. Dean, E. J. Hill, I. Bouybayoune, J. Caron, T. Muliaditan, P. Gordon, D. Sosnowska, R. Nuamah, S. E. Pinder, T. Ng, F. Dazzi, S. Kordasti, D. R. Withers, , J. N. Arnold

This study identifies Lyve-1+ tumor-associated macrophages that support tumor growth by maintaining a pro-angiogenic perivascular niche through platelet-derived growth factor-CC-dependent expansion of mesenchymal cells.

bioRxiv · Oct 30, 2020Cancer Biology