J. Wirbel

Expanding the human gut microbiome atlas of Africa

This study expands the human gut microbiome atlas of Africa by analyzing 1,803 women from four countries, revealing geographic and lifestyle-associated taxa and novel microbial genomes.

Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease

This study uses machine learning to meta-analyze gut microbiome data from Parkinson's disease patients, identifying microbial pathways linked to disease and potential diagnostic applications.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Intragenic DNA inversions expand bacterial coding capacity

The paper identifies intragenic DNA inversions in prokaryotes using long-read sequencing, showing they allow genes to encode multiple protein versions without increasing genome size.

C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants

This study finds that C. difficile is often overdiagnosed in adults and is a common commensal in infants, with distinct microbial associations across age groups.

Dissecting the collateral damage of antibiotics on gut microbes

This study characterizes the antibiotic activity spectrum on gut bacteria, revealing species-specific effects and identifying antidotes to mitigate collateral damage.

Extensive Transmission of Microbes along the Gastrointestinal Tract

The paper shows oral microbes commonly colonize the large intestine in healthy individuals and more so in disease states like colorectal cancer and rheumatoid arthritis.